Authors:

Anak Agung Ngurah Jaya Kusuma

Abstract:

“Systemic lupus erythematosus (SLE) is an auto immune disease which is charaterized by the production of antibodiestowards the nucleus of the cell. The mechanism is not well defined, but there seem to be some exacerbating factors like physicaland metal stress, infection, ultraviolet radiation and drugs. The various cell of our body are recognized as antigen thereforeleading to the formation of immune complexes which will be deposited in organs and eventually cause inflammation. The processwhich affects the placenta is known as deciduas vasculitis. The effects of pregnancy towards SLE in unclear, but the risks ofexacerbation increases as pregnancy advances. Complications such as death of the fetus, premaurity and restricted growth mayoccur. Complication of pregnancy with SLE which affects the fetus characterized by congenital heart block, cutaneus lesion,cytopenia, liver disorders and other systemic manifestation. The pathogenesis of fetal heart block is not well understood, but themechanism seems to be transfers of antibody through the placenta on the second trimester which then will lead to immunologicaltrauma of the heart and its conduction system which will manifest upon delivery. There are two major points to be considered inthe management of SLE in pregnancy; pregnancy can affect the course of SLE and the fetus may become the target of autoantibody which will lead to failure of the pregnancy itself. Corticosteroids have a significant effect and is normally tolerable bymay be considered. Contraception becomes an important key in SLE as estrogens concentration of 20-30 urg/day may exacerbateSLE and will increase the risk of thromboemboli, therefore progesterone containing contraceptives are highly recommended.”

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PDF:

https://jurnal.harianregional.com/jim/full-3828

Published

2021-11-09

How To Cite

JAYA KUSUMA, Anak Agung Ngurah. LUPUS ERITEMATOSUS SISTEMIK PADA KEHAMILAN.journal of internal medicine, [S.l.], nov. 2012. Available at: https://jurnal.harianregional.com/jim/id-3828. Date accessed: 08 Jul. 2024.

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Issue

Vol. 8, No. 2 Mei 2007

Section

Articles

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