Authors:

I Gusti Agung Suryadarma

Abstract:

“Hepatic ischemia reperfusion injury is a complex patho-physiology with a number contributing factors. Ischemia insultcan lead to sublethal cell injury, which is aggravated by the formation of reactive oxygen from various intracellular sources duringreperfusion. In addition, formation of proinflammatory mediators and the recruitment and activation of macrophages, neutrophiland lymphocyte can further enhance the injury. Microcirculatory disturbances lead to underperfused areas in the liver and maycause ischemic injury. Hepatic IR injury involves interaction between different cell types and a variety of cellular and molecularmechanisms including kupffer cells activation, formation of ROS, release of cytokines and chemokines, neutrophil recruitment,mitochondrial permeability transition and pH paradox. There are two distinct phase of liver injury after warm ischemic reperfusion,such as early phases and followed by late phases. Clinical presentation of hepatic ischemic reperfusion injury in sepsis, includingsepsis-associated cholestasis, hepatitis ischemic, cholangitis lenta and progressive sclerosing cholangitis”

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PDF:

https://jurnal.harianregional.com/jim/full-3827

Published

2021-11-09

How To Cite

SURYADARMA, I Gusti Agung. HEPATIC ISCHEMIA REPERFUSION INJURY IN SEPSIS: BASIS PATHOGENIC MECHANISMS.journal of internal medicine, [S.l.], nov. 2012. Available at: https://jurnal.harianregional.com/jim/id-3827. Date accessed: 08 Jul. 2024.

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Issue

Vol. 8, No. 2 Mei 2007

Section

Articles

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