Authors:

Ketut Suega

Abstract:

“Iron deficiency is a widespread nutritional disorder in infant, children and women of reproductive age especially indeveloping countries where almost 2 billion individuals are concerned, particularly infant and children. The absorption ofintestinal iron as regulated in several ways such as dietary regulator, stores regulator and erythropoietic regulator. The negativeconsequence iron deficiency anemia on behavior, psychomotor development and growth rate are well established and underlinedthe need to control iron deficiency anemia. Iron supplementation has proven to be useful, particularly in infant and children,when iron deficiency is important and has to be corrected rapidly. However several studies have indicated that iron deficiencyprotects against infection and other studies show the opposite where morbidity is higher in iron deficient children. Iron deficiencywould decrease the resistance to infection through impairment of immune competence of the individual especially cell-mediatedimmunity. The mechanisms of impairment are very likely multifactorial and may include but not be limited to a reduction in theactivity of certain iron-dependent enzymes such as ribonucleated reductase. Other mechanism may include a defect in one orseveral of the early events of lymphocyte activation and cytokine productions such as IL-2. The main cellular source of IL-2 isactivated lymphocyte and TCR/CD3 actvation leads to autocrine IL-2/high affinity receptor signal transduction, resulting in cellproliferation. Iron deficiency may inactivated T cell proliferation and decreasing IL-2 production.”

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PDF:

https://jurnal.harianregional.com/jim/full-3761

Published

2021-11-09

How To Cite

SUEGA, Ketut. HUBUNGAN BESI DAN PRODUKSI SITOKIN.journal of internal medicine, [S.l.], nov. 2012. Available at: https://jurnal.harianregional.com/jim/id-3761. Date accessed: 28 Aug. 2025.

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Issue

Vol. 7, No. 2 Mei 2006

Section

Articles

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