Authors:

I Gede Gita Sastrawan

Abstract:

“Introduction: Atherosclerosis known as the cause most of cardiovascular disease. Atherosclerosis is a complex pathological process that occurs in the blood vessel. This disease can be triggered by lipid modification, which cause chronic inflammation, eventually lead to thrombosis or stenosis.Result and Discussion: Capsaicin loaded nanoliposome was constructed by extracting capsaicin from chili (Capsicum frutescens L.) using Microwave Assisted Extraction (MAE) method. Then the capsaicin extraction results were constructed with nanoliposome using a thin film hydration method. Capsaicin has LD50 in male Swiss albino mice at 190 mg/kg per oral. Once administered orally, hydrophobic capsaicin will pass through the plasma membrane of endothelial cells and lead to the receptor side of the intracellular vanilloid-binding site reseptor TRPV1 (Transient Receptor Potential Vanilloid 1). The activated TRPV1 is capable of increasing the calcium ion influx which affect the increased expression of ATP-binding cassette transporter A1 (ABCA1) and the decreased expression of LRP1 (low-density lipoprotein protective protein 1). Due to increased Ca2+ influx, endothelial TRPV1 activation also increases PKA phosporilation (protein kinase A) which implies increased UCP2 expression resulting in decreased ROS formation and foam cell formation in atherosclerosis.Conclusion: Capsaicin loaded nanoliposome has potential in the management of atherosclerosis.”

Keywords

Keyword Not Available

Downloads:

Download data is not yet available.

References

References Not Available

PDF:

https://jurnal.harianregional.com/essential/full-47127

Published

2019-02-22

How To Cite

GITA SASTRAWAN, I Gede. CAPSAICIN LOADED NANOLIPOSOME AGONIS TRPV1 : POTENSI TERAPI DALAM PENATALAKSANAAN ATEROSKLEROSIS.Essential: Essence of Scientific Medical Journal, [S.l.], v. 16, n. 2, p. 31-37, feb. 2019. ISSN 2655-6472. Available at: https://jurnal.harianregional.com/essential/id-47127. Date accessed: 28 Aug. 2025.

Citation Format

ABNT, APA, BibTeX, CBE, EndNote - EndNote format (Macintosh & Windows), MLA, ProCite - RIS format (Macintosh & Windows), RefWorks, Reference Manager - RIS format (Windows only), Turabian

Issue

Vol 16 No 2 (2018): Volume 16 No. 2 (Juli-Desember) : Essence Of Scientific Medical Journal

Section

Articles

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License