Authors:

Franky Samuel Milenyano Chandra, I Ketut Berata, I Made Merdana

Abstract:

“Exposure to cigarette smoke can increase the risk of coronary heart disease due to the free radicals generated. One of the plants in Indonesia that contains antioxidants is sappan wood. The purpose of this study was to determine the effect of giving secang wood extract (Caesalpinia sappan Linn) on the histopathological picture of male mice (Mus musculus) after exposure to conventional cigarette smoke. This study used 24 samples of adult male mice aged 35-45 days with body weight between 30-35 grams obtained from a mouse farm in Gianyar, Bali. The sample was divided into 4 treatments with 6 replications, namely negative control without sappan extract treatment and exposure to cigarette smoke, positive control with 2 cigarette smoke exposure a day, 2 cigarette smoke exposure a day and 30 mg/head dose of sappan wood extract. and the treatment was exposed to cigarette smoke as much as 2 cigarettes a day and administration of sappan wood extract at a dose of 60 mg/head, for 30 days. On the 31st day, the experimental animals were sacrificed to take heart muscle and processed into histopathological preparations. The examination was carried out based on the presence of congestion and inflammation lesions. The severity of the lesions was scored as mild, moderate and severe. Observational data were analyzed using the Kruskal-Wallis non-parametric statistical test and continued with the Mann-Whitney test if there was a significant difference. The results showed that there was a significant difference (p<0.05) between mice exposed to cigarette smoke and mice given sappan wood extract after exposure to cigarette smoke. It can be concluded that the administration of sappan wood extract at a dose of 30mg/mouse and 60mg/mouse can improve the heart lesions of male mice after exposure to conventional cigarette smoke. Further research is needed on the use of sappan wood extract with different doses in order to obtain more comprehensive results in treating heart damage after exposure to cigarette smoke.”

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References

  • Aliansi Pengendalian Tembakau Indonesia (APTI). 2013. Peta jalan pengendalian produk tembakau Indonesia. Surakarta, Muhammadiyah University Press.
  • Arnanda QP, Nuwarda RF. 2019. Review article: penggunaan radiofarmaka teknesium-99m dari senyawa glutation dan senyawa flavonoid sebagai deteksi dini radikal bebas pemicu kanker. Fakultas Farmasi, Universitas Padjadjaran. Farmaka. 17(2): 236-243.
  • Barnoya J, Glantz SA. 2005. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 111(20): 2684-2698.
  • Berata IK, Adi AAAM, Winaya IBO, Adnyana IBW, Kardena IM. 2020. Patologi veteriner umum. Swasta Nulus. Denpasar.
  • Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. 2012. Oxidative stress and antioxidant defense. World Allergy Organ. J. 5: 9–19.
  • Chauhan RS. 2007. Illustrated veterinary pathology (general & systemic pathology). International Book Distributing Company. India.
  • Dai JB, Wang ZX, Qiao ZD. 2015. The hazardous effects of tobacco smoking on male fertility. Asian J. Androl. 17(6): 954–960.
  • Davidson. 2003. Seri kesehatan bimbingan dokter pada penyakit jantung koroner. Jakarta: Dian Rakyat.
  • Domej W, Oettl K, Renner W. 2014. Oxidative stress and free radicals in COPD–implications and relevance for treatment. Int. J. Chron. Obstruct. Pulmon. 9: 1207–1224.
  • Evans JL, Goldfine ID, Maddux BA, Grdsky GM. 2003. Are oxidative stress activated signaling pathways mediators of insulin resistance and cell dysfunction?. Diabetes. 52(1) :1-8.
  • Farhana H, Indra TM, Reza AK. 2015. Perbandingan pengaruh suhu dan waktu perebusan terhadap kandungan brazilin pada kayu secang (Caesalpinia sappan Linn.) Prosiding Penelitian Sivitas Akademika UNISBA, Farmasi Gelombang 2, Tahun Akademik 2014 - 2015.
  • Handayani V, Ahmad AR, Sudir M. 2014. Uji aktivitas antioksidan ekstrak metanol bunga dan daun patikala (Etlingera elatior (Jack) R.M.Sm) menggunakan metode DPPH. Fakultas Farmasi, Universitas Muslim Indonesia, Makassar. Pharm. Sci. Res. 1(2): 86-93.
  • Hasriani. 2012. Optimasi proses pengeringan simplisia kayu secang (Sappan lignum) dan aplikasinya pada produk makanan. Sekolah Pascasarjana Institut Pertanian Bogor, Bogor.
  • Info POM. 2015. Bahaya rokok elektrik racun berbalut teknologi. Info POM. 16(5): 3-11.
  • Kiernan JA. 2015. Histological and histochemical methods: theory and practice. 5th. Edition, Scion Publishing, Banbury-United King. Pp. 330-334.
  • Landmesser U, Merten R, Spiekermann S, Buttner K, Drexler H, Hornig B. 2000. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation. 101: 2264–2270.
  • Larasati S, Rahman H, Wigati S. 2020. Gambaran histologis jantung pada pemberian monosodium glutamat (MSG). J. Endurance LLDIKTI X. 5(2): 259-270.
  • Lestari NP, Tjandrakirana, Kuswanti N. 2013. Pengaruh pemberian campuran rebusan secang (Caesalpinia sappan L.) dan daun lidah buaya (Aloe vera) terhadap kadar glukosa darah mencit (Mus musculus). Lentera Bio. 2(1): 113-119.
  • Salbahaga DP, Supartika IKE, Berata IK. 2012. Distribusi lesi negri’s bodies dan peradangan pada otak anjing penderita rabies di Bali. Indon. Med. Vet. 1(3): 352-360.
  • Sumardika IW, Jawi IM. 2012. Ekstrak air daun ubijalar ungu memperbaiki profil lipid dan meningkatkan kadar SOD darah tikus yang diberi makanan tinggi kolesterol. Medicina. 43(2): 67-70.
  • Suryadinata RV, Wirjatmadi B, Adriani M. 2017. Efektivitas penurunan malondialdehyde dengan kombinasi suplemen antioksidan superoxide dismutase melon dan gliadin akibat paparan rokok. Glob. Med. Helath Commun. 5: 79–83.
  • Triadayani AE, Aryawati R, Diansyah G. 2010. Pengaruh logam timbal (Pb) terhadap jaringan hati ikan kerapu bebek (Cromileptes altivelis). Maspari J. 1: 42-47.
  • Werdhasari A. 2014. Peran antioksidan bagi kesehatan. J. Biotek Med. Indon. 3(2):59-68
  • Winarti C, Nurdjanah N. 2005. Peluang tanaman rempah dan obat sebagai sumber pangan fungsional. J. Litbang Pertanian. 24(2): 47-55.

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https://jurnal.harianregional.com/buletinvet/full-89377

Published

2023-03-01

How To Cite

CHANDRA, Franky Samuel Milenyano; BERATA, I Ketut; MERDANA, I Made. EFFECT OF SECANG WOOD EXTRACT ON THE HISPATHOLOGICAL PICTURE OF THE HEART OF THE MALE MICE AFTER EXPOSURE TO CONVENTIONAL CIGARETTE SMOKE.Buletin Veteriner Udayana, [S.l.], p. 674-682, mar. 2023. ISSN 2477-2712. Available at: https://jurnal.harianregional.com/buletinvet/id-89377. Date accessed: 08 Jul. 2024. doi:https://doi.org/10.24843/bulvet.2023.v15.i04.p20.

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Issue

Vol. 15 No. 4 August 2023

Section

Articles

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