MASHED OF PEGAGAN LEAVES ACCELERATES THE HEALING OF BURNS ON WHITE RATS
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Authors:
I Gusti Ngurah Darmalaksana, Luh Made Sudimantini, Anak Agung Gde Jayawarditha, I Ketut Anom Dada
Abstract:
“Burns are an occurrence of skin tissue damage due to contact with the heat source such as fire, chemical, electrical and radiation. Wound handling was done so that the wounds heals faster. This study aims to determine the speed of the second-degree burns healing on white rats (Rattus norvegicus) were given mashed of pegagan leaves (Cantella asiatica (L) Urban) seen from the macroscopic and microscopic descriptions. Thirty-two female white rats weighing 150-200 grams were divided into two treatments, each treatment consisting of 16 rats, area burns treatment performed on the dorsal of rats with diameter of 1 centimeters. Giving mashed of pegagan leaves as much as three sheets with the size of 2x1 centimeters. Macroscopic observation were performed daily for 14 days. On the seventh day and day 14, all rats had euthanasia, then skin burns were collected for microscopic examination.The result of macroscopic examination were analyzed by Chi-Square and Analysis of variant, whereas histopathologic examination were analyzed using the Mann-Whitney. The result of macroscopic examination of the wound diameters, inflammation marks, swelling and scarring were significantly different. Thus, by giving mashed of pegagan leaves had significant effect on the control rats. On microscopic examination were analyzed by the Mann-Whitney were significantly different in the epithelial cells at the seventh day Giving mashed of pegagan leaves were accelerate the healing of second degree burns on white rats.”
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References
- Artawan IK, Jawi IM, Mayati LG. 2013. Efek Ekstrak Gel Daun Pegagan (Centella Asiatica) dalam Mempercepat Waktu Enyembuhan Luka pada Tikus Putih (Rattus Norvegicus Strain Wistar). Open J. Syst. 1(2).
- Belcaro, Maquart GFX, Scoccianti M, Dugall M, Hosoi M, Cesarone MR, Luzzi R, Cornelli U, Ledda A and Feragalli B. 2011. TECA (Titrated Extract of Centella Asiatica): New Microcirculatory Biomolecular and Vascular Application in Preventive and Clinical Medicine. Panminerva Med. 53(3 Suppl 1): 105-118.
- Celloti F, Laufer. 2001. Inflammation Healing and Repair Synopsis. J. Pharm. Res. 43(5).
- Cyntia A. 2012. Perbandingan Tingkat Kesembuhan Luka Sayat Terbuka Antara Pemberian Povidon Ipuodin Dan Pemberian Propolis Secara Topikal Pada Tikus Putih (Rattus novergicus). Skripsi. Lampung: Fakultas Kedokteran Universitas Lampung.
- Eriawan R, Rosida I, Prastyawan Y, Bunga O, Erna Y. 2013. Efektivitas Khasiat Pengobatan Luka Bakar Sediaan Gel Mengandung Fraksi Ekstrak Pegagan Berdasarkan Analisis Hidroksiprolin dan Histopatologi Pada Kulit Kelinci. Bul. Penelit. Kesehat. 41: 45-60.
- Hanum SF, Warseno T. 2015. Ethnomedicine tumbuhan obat tradisional masyarakat Bali. Proc. Ekspose dan Seminar Pembangunan Kebun Raya Daerah. 2015: 905-916.
- Hendrayana KA, Suwiti NK, Kardena IM, Besung INK. 2013. Pengaruh Pemberian Pegagan (Centella asiatica) Terhadap Gambaran Mikroskopis Ginjal Mencit yang Diinfeksi Salmonella typhi. Bul. Vet. Udayana. 5(1): 41-47.
- Kanalagi SJR. 2011. Peran Intergen Pada Angiogenesis Penyembuhan Luka. Cermin Dunia Kedokteran 184. 38(3): 177-181.
- Kiernan JA. 1990. Histological & Histochemical Methods: Theory & Practice. 2nd Ed. Pergamon England.
- Lostapa IWFW, Warditha AAGJ, Pemayun IGAGP, Sudimartini NLM. 2015. Kecepatan kesembuhan luka insisi yang diberi amoksisilin dan asam mefenamat pada tikus putih. Bul. Vet. Udayana. 8(2): 172-179
- Mitchell RN and Cotran RS. 1997. Repair Cell regeneration, fibrosis, and wound healing. In: Kumar V, Cotran RS, Robbins SL (eds). WB. Saunders Company. 6: 47-59.
- Poela S, Aang S. 2014. Uji Aktivitas Anti Radang Ekstrak Etanol Biji Pinang (Areca catecliu L.) Pada Tikus Putih Jantan. Indonesian J. Pharm. Technol. 3(2): 8-14.
- Supardi S, Handayani RS, Herman MJ, Raharni, Susyanty. Kajian peraturan perundang-undangantentang pemberian informasiobat dan obat tradisional di indonesia. J Kefarmasian Indonesia. 2((1): 20-27.
- Suwiti NK. 2010. Deteksi histologik kesembuhan luka pada kulit pasca pemberian daun mengkudu (Morinda citrofilia Linn). Bul. Vet. Udayana. 2(1): 1-9.
- Tiwiari S, Gehlot S, Gambhir IS. 2011. Centella Asiatica: A Concise Drug Review with Probable Clinical Uses. J. Stress Physiol. Biochem. 7: 38-44.
- Toyoda M, Takayama, Horiguchi N, Otsuka T, Fukusato T, Merlino G, Takagi H, Mori M. 2001. Overexpression of hepatocyte growth factor scatter factor promotes vascularization and granulation tissue formation in vitro. FEBS Lett. 509: 95-100.
- Wijaya RA, Latifah, Pratjojo W. 2013. Formulasi Krim Ekstrak Lidah Buaya (Aloe vera) Sebagai Alternatif Penyembuhan Luka Bakar. Indonesian J. Chem. Sci. 3: 212-217.
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https://jurnal.harianregional.com/buletinvet/full-31742
Published
2018-08-27
How To Cite
DARMALAKSANA, I Gusti Ngurah et al. MASHED OF PEGAGAN LEAVES ACCELERATES THE HEALING OF BURNS ON WHITE RATS.Buletin Veteriner Udayana, [S.l.], p. 137-146, aug. 2018. ISSN 2477-2712. Available at: https://jurnal.harianregional.com/buletinvet/id-31742. Date accessed: 02 Jun. 2025. doi:https://doi.org/10.24843/bulvet.2018.v10.i02.p06.
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Vol. 10 No. 2 Agustus 2018
Section
Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License
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