Authors:

MAHRIANI -

Abstract:

“The disturbance of spermatogenesis after exposure with 2,5-HD (2,5-Hexanedione) can be observed through the increasing of death cell in apoptosis mechanism, that can be observed through the expression of Bax protein. Therefore, it had been conducted a research to study the expression of Bax protein against white mouse of Wistar strain exposured with 2,5-HD. A number of 56 white mouse were divided randomly into 8 groups, each group consists of 7 white mouse, two groups were used as pretest, three groups used as control treatment, and three groups used as treatment were exposured with 2,5-HD of 0,06 mg/WW during 2, 4, 6 week. The changes in the Bax protein expression observed in the slices of cross section of testis using imunohistochemical method. The research result shows that the longer duration of 2,5-HD exposure causes the more increase the expression of Bax protein at the sertoli cell and the germinal. The expression of Bax protein compared to the control groups increases into 132%, 112%, 108% and 123% respectively for the sertoli, spermatogonial, spermatocyt, and spermatid cells in the treatment were exposured with 2,5-HD during 6 weeks. It is needed a further research to complete information of apoptosis mechanism as the result of 2,5-HD exposure, by study the ratio of Bcl-2/Bax expression as the antiapoptosis and proapoptosis proteins.”

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PDF:

https://jurnal.harianregional.com/bio/full-568

Published

2008-06-01

How To Cite

-, MAHRIANI. KAJIAN EKSPRESI PROTEIN BAX PADA GANGGUAN SPERMATOGENESIS PASCA PEMAPARAN 2,5-HEXANADIONE, PADA TIKUS PUTIH (RATTUS NORVEGICUS L).Jurnal Biologi Udayana, [S.l.], v. 12, n. 1, p. -, june 2008. ISSN 2599-2856. Available at: https://jurnal.harianregional.com/bio/id-568. Date accessed: 28 Aug. 2025.

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Issue

Vol 12 No 1 (2008): JURNAL BIOLOGI

Section

Articles

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