RELATIONSHIP OF URINARY C-TERMINAL TELOPEPTIDE COLLAGEN TYPE-II (CTX-II) LEVEL WITH THE DEGREE OF JOINT DAMAGE IN PATIENTS WITH KNEE OSTEOARTHITIS

Authors:

Kusworini Handono, Farida **, BP Putra Suryana, Enny Listyawati

Abstract:

“Radiography of the knee is used to confirm the diagnosis and classification of knee OA severity. Urinary CTX- II is a biochemical marker for assessing cartilage degradation of knee OA. This research aimed to analyze the correlation between the level of urinary CTX-II and the radiographic severity of knee OA. Research was conducted in 40 patients with knee OA ( ACR criteria ) and 40 age and sex matched healthy controls. Wheight bearing anteroposterior and lateral semiflexed radiographs were taken of both knee. The patients were stratified based on the Kellgreen-Lawrence (K-L) score. Urinary CTX-II level was measured using ELISA competitive method. Correlation between urinary CTX-II level and radiographic knee OA severity was analyzed with Spearman Correlation. Statistical significance level at P < 0.05. Mean urinary CTX-II level was significantly higher in patients with OA compared with healthy controls (447.7( SB 316.39) ng/ml vs 289(SB 168.01) ng/mmol respectively, P = 0.023). There was a significant difference between urinary CTX-II level in patients with grade ? 2 K-L knee OA compared with patients with grade > 2 K-L (240.35 (SB 88.90) ng/mmol vs 728.24 (SB 295.15) ng/mmol respectively; P < 0.001). The urinary CTX-II level was significantly associated with the degree of joint lesion in patients with OA (r = 0.734; P = 0.0001). Urinary level of CTX-II is strongly associated with the degree of radiographic joint lesion of OA”

Keywords

Keyword Not Available

Downloads:

Download data is not yet available.

References

References Not Available

PDF:

https://jurnal.harianregional.com/medicina/full-5065

Published

2021-11-09

How To Cite

HANDONO, Kusworini et al. RELATIONSHIP OF URINARY C-TERMINAL TELOPEPTIDE COLLAGEN TYPE-II (CTX-II) LEVEL WITH THE DEGREE OF JOINT DAMAGE IN PATIENTS WITH KNEE OSTEOARTHITIS.Medicina, [S.l.], v. 43, n. 3, apr. 2013. ISSN 2540-8321. Available at: https://jurnal.harianregional.com/medicina/id-5065. Date accessed: 28 Aug. 2025.

Citation Format

ABNT, APA, BibTeX, CBE, EndNote - EndNote format (Macintosh & Windows), MLA, ProCite - RIS format (Macintosh & Windows), RefWorks, Reference Manager - RIS format (Windows only), Turabian

Issue

Vol 43 No 3 (2012): September 2012

Section

Articles

Copyright

This work is licensed under a Creative Commons Attribution 4.0 International License