Authors:

Ida Bagus Putra Pramana, Ketut Putu Yasa

Abstract:

“The mechanism of wound healing is a complex mechanism and involves a variety of cells. Injury is defined as a disruption of normal structure and function. Various types of growth factors and cytokines such as platelet derived growth factor and transforming growth factor beta involved in the mechanism of wound healing. There are four phases of wound healing mechanisms : hemostasis, inflammatory, proliferative, and remodeling. Diabetic ulcers is one major complication, occurring in 15% of patients with diabetes mellitus (DM) and as much as 84% of patients with diabetic ulcers require amputation action. In DM patients there is a failure in normal wound healing mechanisms. Various histopathological studies showed elongation phase of inflammation in patients with diabetes mellitus, thus inhibiting the formation of granulation tissue. Increased blood sugar levels will lower the expressin of perlecan, increased advanced glycation endproducts, decreased the formation of nitric oxide (by ± 67%), changes in the structure and function of fibroblasts and increased activity of matrix metalolproteinases, it will cause distruption of the normal wound healing mechanisms. (MEDICINA 2012;43:49-53).”

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PDF:

https://jurnal.harianregional.com/medicina/full-4952

Published

2021-11-09

How To Cite

PUTRA PRAMANA, Ida Bagus; YASA, Ketut Putu. WOUND HEALING IN DIABETIC ULCER.Medicina, [S.l.], v. 43, n. 1, mar. 2013. ISSN 2540-8321. Available at: https://jurnal.harianregional.com/medicina/id-4952. Date accessed: 28 Aug. 2025.

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Issue

Vol 43 No 1 (2012): Januari 2012

Section

Articles

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License