Authors:

Ketut Suega

Abstract:

“Iron is an essential substance needed for metabolism process, such as for transporting oxygen to the tissues for energyproduction in cells. Iron is also important for transporting electrons in the mitochondria for cell respiration process, andfor synthesizing Deoxyribo Nucleic Acid (DNA). In addition to its role in oxygen transport and metabolic pathways, ironplays a pivotal role in immune function by promoting lymphocyte activation and proliferation. On the other hand, ironover-load can have immune disorders and yet pathogenic microorganism require iron for their growth and proliferation.Therefore iron homeostasis must be maintained through careful regulation of duodenal absorption and recycling of ironstores since human body has no ideal excretory system for iron. Discovery of hepcidin peptide help clarify molecularbased of cellular interaction between duodenal iron absorption capacity and iron stores cells. Hepcidin a putative negativehumoral regulator of iron homeostasis by inhibiting iron absorption and couple with ferroportin preventing iron exportedfrom intracellular iron stores. Hepatic hepcidin expression is increased in iron overload and decreased in iron deciency. Inaddition to regulation by body iron needs, hepcidin is increased during an acute phase respone of inlammation processed.When an in!ammation is initiated, liberation of proin!ammatory cytokine IL-6 stimulate hepcidin expression causingiron absorption and iron release from the macrophage of the reticuloendotheleal system are decreased. Many other studieson humans and experimental animals have shown signicant change of the levels of certain cytokines in iron deciencystate such as IL-2; IL-4; IL-6; IL-10; IL-12; IFN gamma. As summarized, cytokines in!uence iron homeostasis and in theother way iron in!uences activity of cytokines and immune effector mechanism of macrophages, and all these affect thelevel of immune defence against invading pathogens.”

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PDF:

https://jurnal.harianregional.com/jim/full-3965

Published

2021-11-09

How To Cite

SUEGA, Ketut. INTERRELASI BESI DENGAN SITOKIN DAN VICE VERSA.journal of internal medicine, [S.l.], apr. 2014. Available at: https://jurnal.harianregional.com/jim/id-3965. Date accessed: 28 Aug. 2025.

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Issue

Vol. 13, No. 1 Januari 2012

Section

Articles

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License