Authors:

I Made Rama Putra, Ketut Suega

Abstract:

“Protein C is a natural anticoagulant, inhibits thrombin generation. Protein C de! ciency, is associated with a variablyincreased risk of thrombosis. Incidence of symptomatic protein C de! ciency is approximately 1 in 16,000 to 1 in 32,000 persons,similar in men and women. Morbidity in protein C de! ciency greatly increases with advancing age, when patients are at greaterrisk for thrombotic events such DVT, PE, postphlebitic and blindness secondary to vitreous hemorrhages may occur in patientswith these severe conditions. The etiology can be inherited and acquired in a number of clinical scenarios include meningococcalseptic shock; DIC; liver disease; or chemotherapy. Diagnostic base on personal history of venous thrombosis, thromboembolicevents, abnormal laboratory coagulation tests. The laboratory workup should include haemostatic parameters, coagulationsystem such aPTT, PT, ! brinogen level and D-dimer test. A decreased protein C activity level is required. Imaging studies areappropriate for assessing the presence of thrombotic disease in a particular vessel. The treatment depends largely on a particularpatient?s disease manifestations. Surgical treatment may be appropriate in some circumstances.We reported, a male Balinese 62 years old came with complain red vision and dull feeling since a moth prior toadmission. No historical medical problem found. Physical exam found hypertension and laboratory ! nding showed slightdyslipidemia. Ophthalmologic examination revealed BRVO (Branch Retinal Vein Occlusion) ocular sinistra. Hypercoagulablaestate are suspected. Hematologic exam revealed light hyperagregation and low level of protein C and protein S. Treated withheparin 5000 unit intravenously followed by drip 1000 unit per hour for 3 day continued with warfarin 4 mg OD reach INR 1.5? 2.5. Good resulted base on patient?s good compliance.”

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PDF:

https://jurnal.harianregional.com/jim/full-3949

Published

2021-11-09

How To Cite

RAMA PUTRA, I Made; SUEGA, Ketut. THROMBOPHILIA KARENA DEFISIENSI PROTEIN C DAN PROTEIN S.journal of internal medicine, [S.l.], nov. 2012. Available at: https://jurnal.harianregional.com/jim/id-3949. Date accessed: 02 Jun. 2025.

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Issue

Vol. 11, No. 2 Mei 2010

Section

Articles

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