Authors:

Ketut Suega

Abstract:

“Reticulocytes are immature nonnucleated erythrocytes that are released from the bone marrow following enucleation ofthe normoblast. Under the in! uence of erythropoietin, committed erythroid progenitor cells divide and differentiate through aseries of stages, giving rise basophilic normoblasts, polychromatophilic normoblasts, and orthochromic normoblastsin sequence.Reticulocytes are similar to mature red blood cells, except that they retain functioning polyribosomes and continue to synthesizehemoglobin. Because the reticulocyte stage of erythroid differentiation only lasts a few days, the number of reticulocytes in theblood is a useful clinical indicator of the rate of erythropoiesis. Reticulocytes exist in the circulation for only 1 ? 2 days and signalthe marrow erythropoietic activity 3 ? 4 days after iron was actively incorporated into haemoglobin. Early changes in reticulocytecount may simply re! ect the release of immature reticulocytes from the marrow rather than the true expansion of erythropoiesis.Reticulocyte counts have once again acquired great interest and importance following the introduction of instruments that usedyes speci” c for RNA. This has resulted in precise and accurate counts even at low reticulocyte concentrations The latestgeneration of automated analyzer provides additional information on reticulocytes, such as the immature reticulocyte fraction(IRF) and other reticulocyt indices, eg, mean reticulocyte volume (MCVr) and mean reticulocyte haemoglobin content (CHr).To date, the most widely studied of the reticulocyte indices is the CHr. The hemoglobin content is considered to be constantthroughout the lifetime of erythrocytes and circulating reticulocytes1 unless structural changes take place that compromise theamount of cytoplasm or cause cellular fragmentation. The normal value for the ! owcytometry method can range from 1% to2% depending on the cut off point used to separate reticulocytes from the normal red blood cell population. Since reticulocyteenumeration provides information about the bone marrow activity and the effectiveness of red blood cell production, it is crucialin the clinical application of reticulocytes parameters to aid the diagnosis of anemic patients, and for monitoring bone marrowtransplantation patients, patients undergoing therapy with marrow toxic drugs, and patients being treated for anemia”

Keywords

Keyword Not Available

Downloads:

Download data is not yet available.

References

References Not Available

PDF:

https://jurnal.harianregional.com/jim/full-3900

Published

2021-11-09

How To Cite

SUEGA, Ketut. APLIKASI KLINIS RETIKULOSIT.journal of internal medicine, [S.l.], nov. 2012. Available at: https://jurnal.harianregional.com/jim/id-3900. Date accessed: 28 Aug. 2025.

Citation Format

ABNT, APA, BibTeX, CBE, EndNote - EndNote format (Macintosh & Windows), MLA, ProCite - RIS format (Macintosh & Windows), RefWorks, Reference Manager - RIS format (Windows only), Turabian

Issue

Vol. 11, No. 3 September 2010

Section

Articles

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License