Authors:

Putu Pradnya Pramita Dewi

Abstract:

“ABSTRACT Atherosclerosis is a chronic inflammatory disease that begins with endothelial dysfunction, it caused fat accumulation and plaque growth in the inner arteries walls. Endothelial dysfunction will activate the Nuclear Factor Kappa B (NF-kB) pathway involving IKK proteins. Terpinen4-ol is constituent found in the bangle (Zingiber cassumunar) rhizome. The purpose of this study were to determine the affinity and mechanisms of terpinen-4-ol against IKK protein as anti-inflammatory in atherosclerosis performed using molecular docking method. The docking result are assessed from the binding energy and hydrogen bonds formed between terpinen-4-ol and protein. The result showed that terpinen-4-ol has activity in inhibiting the inflammatory process because it is able to disturb IKK protein with bond energy values -4.89 kcal/mol. The molecular mechanism in inhibiting the activity of IKK protein through the formation of hydrogen bonds in these proteins. These result show that terpinen-4-ol has the potential to inhibiting inflammatory process and it caused the formation of atherosclerotic plaque can be obstructed. Keywords: Atherosclerosis, Terpinen-4-ol, Molecular Docking, In Silico”

Keywords

Atherosclerosis, Terpinen-4-ol, Molecular Docking, In Silico

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PDF:

https://jurnal.harianregional.com/jfu/full-47499

Published

2019-07-27

How To Cite

DEWI, Putu Pradnya Pramita. Molecular Docking Terpinen-4-ol pada Protein IKK sebagai Antiinflamasi pada Aterosklerosis secara In Silico.Jurnal Farmasi Udayana, [S.l.], p. 44, july 2019. ISSN 2622-4607. Available at: https://jurnal.harianregional.com/jfu/id-47499. Date accessed: 28 Aug. 2025. doi:https://doi.org/10.24843/JFU.2019.v08.i01.p07.

Citation Format

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Issue

Vol. 8, No. 1, Tahun 2019

Section

Articles

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License