Authors:

I M. A. G. Wirasuta, M. A. Ningtyas, E. I. Setyawan

Abstract:

“Heroine is hydrolyzed spontaneously in water and plasma. This will influence the determination, especially on the drug profiling. Spectrophotodensitometry has been used to analyze drug profiling of illicit heroine. This article reports the AL-TLC separation of heroine, 6-monoacetylmorphine (6-MAM), morphine, acetyl codeine, and the heroine hydrolysis in water and plasma. Heroin, 6-MAM, morphine, and acetyl codeine can be well-separated by mobile phase of toluene:siclohexane:diethyl amine (75:15:10, v/v). The limit of detection was 165.16 ng/spot and the limit of quantification was 550.55 ng/spot. Heroine was hydrolyzed in water and plasma under first order reaction. The rate of reaction was 0.55 min-1 in water with the half time reaction of 12.47 minutes. On the other hand the hydrolysis rate in plasma was slower with the half time of 16 minutes. Keywords : hydrolysis, heroin, water, TLC-spectrophotodensitometer”

Keywords

: hydrolysis, heroin, water, TLC-spectrophotodensitometer

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PDF:

https://jurnal.harianregional.com/jchem/full-51717

Published

2019-07-31

How To Cite

WIRASUTA, I M. A. G.; NINGTYAS, M. A.; SETYAWAN, E. I.. LAJU HIDROLISIS HEROIN DALAM AIR DAN PLASMA.Jurnal Kimia (Journal of Chemistry), [S.l.], p. 191-195, july 2019. ISSN 2599-2740. Available at: https://jurnal.harianregional.com/jchem/id-51717. Date accessed: 28 Aug. 2025. doi:https://doi.org/10.24843/JCHEM.2019.v13.i02.p11.

Citation Format

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Issue

Vol.13 No.2 Juli 2019

Section

Articles

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