Authors:

Kadek Karina Dewi Wijayanthi, I Ketut Berata, Samsuri Samsuri, I Wayan Sudira

Abstract:

“Dexamethasone it’s in period a synthetic corticosteroid drug that widely used by the public. If it used for long time and the use of large doses, causing oxidative stress in cells due to the accumulation of free radicals which may cause cell death in the body organs tissues. Vitamin E was known to have a good role as an antioxidant effect. Currently, unknown effects of dexamethasone and vitamin E administration on damage of the small intestine of rat (Rattus norvegicus). This study used an experimental design. Samples 25 male rats were divided into 5 groups, namely the negative control or no treatment (P0), positive control (P1) was given dexamethasone Harsen 0.13 mg/kg, and the treatments were given dexamethasone Harsen 0.13 mg/kg with a varieties of vitamins E (Natur-E) multilevel namely P2 (100 mg / kg), P3 (150 mg / kg), and P4 (200 mg / kg). After the treatment was given for 2 weeks, the mice at necropsied and the small intestine were taken for histopathological examination using hematoxyline-eosin staining. Results showed treatment P1 found severe necrosis (caseosa) in the small intestine, while the entire treatment P2, P3, and P4 affect the repair of damage due to effects of the dexamethasone. Treatment 4 (P4) was the best results in reducing the effects of dexamethasone.”

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References

  • Dharma IGBS, Berata IK, Samsuri. 2015. Studi histopatologi pankreas tikus putih (Rattus novergicus) yang diberi deksametason dan suplementasi Vitamin E. Indon Med Vet 4(3): 257-266.
  • Fromm MF, Busse D, Kroemer HK Eichelbaum M. 1996. Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin. Hepatology 24: 796-801.
  • Guyton AC, Hall JE. 2000. Textbook of Medical Physiology. 10th Ed. Philadelphia, WB Saunders Company. Pp: 875-879.
  • Halliwell B, Gutteridge JMC. 1999. Free radicals in biology and medicine. third edition. New York: Oxford Univ Pr Inc.
  • Holtbecker N, Fromm MF, Kroemer HK, Ohnhms EF, Heidemann H. 1996. The nifedipinerifampin interaction: Evidence for induction of gut wall metabolism. Drug Metab Dispos 24: 1121-1123.
  • Indranarum T, Marowardoyo S. 2003. Kadar plasma kortisol pada beberapa macam manifestasi efek samping kortikosteroid pada kulit. J Berkala Ilmu Penyakit Kulit dan Kelamin 15.
  • Insani A, Samsuri, Berata IK. 2015. Gambaran Histopatologi Hati Tikus Putih yang Diberikan Deksametason dan Vitamin E. Indon Med Vet 4(3): 228-237.
  • Katzung GB. 2002. Farmakologi dasar dan klinik. Penerjemah dan editor: Bagian Farmakologi Fakultas Kedokteran Universitas Airlangga. Ed 8. Jakarta: Salemba Medika, pp: 582-590.
  • Krishna DR, Klotz U. 1994. Extrahepatic metabolism of drugs in humans. Clin Pharmacokinet 26: 144-160.
  • Kusumaadhi ZM. 2010. Pengaruh pemberian deksametason dosis bertingkat per oral 30 hari terhadap kerusakan mukosa lambung tikus Wistar. Universitas Diponegoro.
  • Lin JH, Chiba M, Baillie TA. 1999. Is the role of the small intestine in first-pass metabolism overemphasized. Pharmacol Rev 51: 135-158.
  • Paine MF, Shen DD, Kunze KL, Persins JD, Marsh CL, McVicar JP, Barr DM, Gillies BS, Thummel KE. 1996. First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther 60: 14-24.
  • Renwick AG, George CF. 1989. Metabolism of xenobiotics in the gastrointestinal tract, in intermediary xenobiotic metabolism in animals: methodology, mechanisms and significance. Taylor & Francis, London, pp: 13-40.
  • Ranta F, Avram D, Berchtolf S, Dufer M, Drews G, Lang F, Ullrich S. 2006. Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4. USA. American Diabetes Association.
  • Ridho MR. 2010. Pengaruh pemberian deksametason dosis bertingkat per oral 30 hari terhadap kerusakan tubulus ginjal tikus Wistar. Fakultas Kedokteran. Universitas Diponegoro.
  • Samsuri, Rahardjo, Sudjarwo. 2011 . The influences of dexamethasone sodium phosphate to insulin and glucose level in young male rats body (Rattus norvegicus). Asosiasi Farmakologi dan Farmasi Veteriner Indonesia.
  • Sativani I. 2010. Pengaruh pemberian deksametason dosis bertingkat per oral 30 hari terhadap kerusakan sel hepar tikus Wistar. Fakultas Kedokteran. Universitas Diponegoro.
  • Stell RGD, Torrie JH. 1991. Principles and Procedures of Statistic. A Biomedical Approach. Second Edition. Tokyo: Mc. Grow Hill.
  • Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. 1995. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine. Clin Pharmacol Ther 58:492–497.

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https://jurnal.harianregional.com/buletinvet/full-28732

Published

2017-02-08

How To Cite

WIJAYANTHI, Kadek Karina Dewi et al. HISTOPATHOLOGY SMALL INSTESTINE OF MALE WHITE RATS THAT WERE DEXAMETHASONE AND VITAMINE E SUPLEMENTED.Buletin Veteriner Udayana, [S.l.], feb. 2017. ISSN 2477-2712. Available at: https://jurnal.harianregional.com/buletinvet/id-28732. Date accessed: 08 Jul. 2024.

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Issue

Vol. 9 No. 1 Pebruari 2017

Section

Articles

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