Authors:

Nur Mufida, Nour Athiroh Abdoes Sjakoer, Nurul Jadid Mubarakati

Abstract:

“One of the diseases that become a health problem because of the increasing prevalence every year is hypertension. The high of ROS (Reactive Oxygen Species) in the body will increase the formation of excess free radicals and make the endogenous antioxidant SOD (Superoxide dismutase) be used in excess so that it becomes the cause of the emergence of hypertension. Herbal tea parasite and mango parasite are plants that have the potential to prevent hypertension by increasing SOD activity in the body. The purpose of this study was to determine the effect of exposure to a combination of methanolic extract of tea parasite and mango parasite (CMETMMM) on increasing serum SOD levels in DOCA-salt-induced hypertension rats using a preventive model. In this study, experimental methods were used with 25 male Wistar rats as test animals which were divided into 5 groups and there were 5 rats in each group, namely negative control (K-), positive control (K+), and group with CMETMMM exposure treatment (P1) at a dose of 50 mg/kgBW, (P2) at a dose 100 mg/kgBW, and (P3) at a dose 200 mg/kgBW. The results showed that CMETMMM exposure had an effect on increasing serum SOD activity in hypertensive rats with a significant difference in the mean value between all groups with p-value <0,05. The effectiveness of exposure to tea parasite and mango parasite was controlled by CMETMMM at a dose of 100 mg/KgBW which is an effective dose in increasing SOD serum levels of rats with DOCA-Salt hypertension model.”

Keywords

Keyword Not Available

Downloads:

Download data is not yet available.

References

  • Aini SQ, Athiroh NAS, Mubarakati NJ. 2021. Kadar Superoksida Dismutase (SOD ) pada Paru-Paru Tikus Hipertensi Doca-Garam yang Dipapar Ekstrak Metanol Benalu Teh dan Benalu Mangga. Metamorfosa: Journal of Biological Sciences 8(2): 291.
  • Athiroh ASN, Permatasari N. 2012. Mekanisme Kerja Benalu Teh pada Pembuluh Darah. Jurnal Kedokteran Brawijaya 27(1): 1–7
  • Athiroh N, Permatasari N. 2011. Mekanisme Deoxycorticosterone Acetate (Doca)-Garam terhadap Peningkatan Tekanan Darah pada Hewan Coba. El-Hayah 1(4): 199–213
  • Athiroh NA. 2017. Monograf Benalu Teh dan Hipertensi. Inteligensia Media: Malang
  • Badyal DK, Lata H, Dadhich AP. 2003. Animal Models of Hypertension And Effect of Drugs. Indian Journal of Pharmacology 35(6): 349–362
  • Kurniawati A. 2019. Pengaruh Jenis Pelarut pada Proses Ekstraksi Bunga Mawar dengan Metode Maserasi sebagai Aroma Parfum. Journal of Creativity Student 2(2): 74–83
  • Madihah M, Alfina F, Gani YY. 2016. Blood Glucose Level and Pancreas Histological Section of Mice ( Mus musculus L.) Induced By Alloxan After Treatment of Curcuma mangga Val. Rhizome Extract. Jurnal Biologi Udayana 20(2): 64.
  • Murray RK, Granner DK, Rodwell VW. 2009. Biokimia Harper. Buku Kedokteran EGC: Jakarta
  • Ohashi K, Winarno H, Mukai M, Inoue M, Prana MS, Simanjuntak P, Shibuya H. 2003. Indonesian Medicinal plants. XXV: Cancer Cell Invasion Inhibitory Effects of Chemical Constituents in the Parasitic Plant Scurrula atropurpurea (Loranthaceae). Chemical and Pharmaceutical Bulletin 51(3): 343–345.
  • Permatasari SN, Umarudin. 2019. Determinasi dan Analisa Proksimat Daun Benalu pada Pohon Mangga Arum Manis di Ketintang Madya Surabaya. Journal of Pharmacy and Science 4(2): 77–83.
  • Pratiwi M., Kawuri R, Ardhana IP. 2019. Potensi Antibakteri Limbah Kulit Durian (Durio zibethinus Murr .) terhadap Propionibacterium Acnes Penyebab Jerawat. Jurnal Biologi Udayana 23(1): 8–15
  • Vaziri ND, Rodríguez-Iturbe B. 2006. Mechanisms of Disease: Oxidative Stress and Inflammation in the Pathogenesis of Hypertension. Nature Clinical Practice Nephrology 2(10): 582–593.
  • Verdiana M, Widarta IWR, Permana IDGM. 2018. Pengaruh Jenis Pelarut pada Ekstraksi Menggunakan Gelombang Ultrasonik terhadap Aktivitas Antioksidan Ekstrak Kulit Buah Lemon (Citrus limon (Linn.) Burm F.). Jurnal Ilmu dan Teknologi Pangan (ITEPA) 7(4): 213.
  • Widowati W, Safitri R, Rumumpuk R, Siahaan M. 2005. Penapisan Aktivitas Superoksida Dismutase pada Berbagai Tanaman. Jkm 5(1): 33–48
  • Winarsi H. 2007. Antioksidan Alami dan Radikal Bebas: Potensi dan Aplikasinya dalam Kesehatan. Penerbit Kanisius: Yogyakarta

PDF:

https://jurnal.harianregional.com/bio/full-82871

Published

2022-06-09

How To Cite

MUFIDA, Nur; SJAKOER, Nour Athiroh Abdoes; MUBARAKATI, Nurul Jadid. Exposure of parasites (tea and mango) to Superoxide Dismutase (SOD) levels of hypertension rat serum on preventive model.Jurnal Biologi Udayana, [S.l.], v. 26, n. 1, p. 58-65, june 2022. ISSN 2599-2856. Available at: https://jurnal.harianregional.com/bio/id-82871. Date accessed: 08 Jul. 2024. doi:https://doi.org/10.24843/JBIOUNUD.2022.v26.i01.p06.

Citation Format

ABNT, APA, BibTeX, CBE, EndNote - EndNote format (Macintosh & Windows), MLA, ProCite - RIS format (Macintosh & Windows), RefWorks, Reference Manager - RIS format (Windows only), Turabian

Issue

Vol 26 No 1 (2022): JURNAL BIOLOGI UDAYANA

Section

Articles

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License